American college student, Amanda Knox, embarks on her study abroad trip in Italy. The morning before Amanda is supposed to leave on a romantic excursion with her new Italian boyfriend, Raffaele Sollecito, things take a sinister turn.

As Amanda, Raffaele, and Patrick Lumumba enter prison, Giuliano Mignini, their prosecutor, continues to build his case against them while the media's reporting turns Amanda into a monster.