As part of Channel 4's annual Stand Up to Cancer campaign, hosts Adam Hills, Josh Widdicombe and Alex Brooker and guests Kathy Burke and Harry Hill help raise awareness for Cancer Research UK. Plus, the usual comic review of the significant moments of the past seven days as the UK continues its rollercoaster ride towards Brexit. As usual, the hashtag #isitok paves the way for the gang to round up, examine and explain the leading and most entertaining news stories of the week.

Aisling Bea and Nish Kumar join Adam, Josh and Alex in the studio.