Norman Osborn hires the Hobgoblin to assassinate Wilson Fisk, also known as The Kingpin, because of the crime lord's continuous threats against him. Peter Parker saves Fisk just as the Hobgoblin attempts an attack on him. After eluding Spider-Man, the Hobgoblin is fired by Norman as of his unsuccessful assassination on The Kingpin.

The Chameleon, an international spy, attempts assassination on two diplomats in order to derail the signing of a peace proposal. J. Jonah Jameson assists S.H.I.E.L.D. in an effort to prevent the Chameleon's crime.