J. Jonah Jameson and many others believe that Spider-Man is responsible for robberies that have been happening recently. Peter thus decides to search for clues to prove that these robberies were caused by a Spider-Man imposter. He teams up with Detective Lt. Terry Lee in search for clues and confronts Mysterio, a self proclaimed master of the mystic arts.

Peter Parker has an interview with a scientist named Mariah Crawford. When Peter gets to her office she is under attack by the villain Kraven the Hunter. After Spider-Man is able to elude him Dr. Crawford explains that Kraven and her used to be in love but when he was seriously injured by some lions she had no choice but to give him this wonder drug, left by a former associate of her that can heal all wounds.