Commanders Lexi and Ethan choose Dexx the tech genius Ben, Jamie and Ben guide Vaygus the smuggler, Logan, Bobby and Cody work with Zarq the secret agent, and Ayesha, Daniyal and Maria direct cool-under-pressure, Tal. They have to make it through the cyber factory to test the antivirus. If any of them can succeed, it will help Skye to save her people.

Commanders Kaitlyn and Atlanta direct Brodie, the rebel, Katie and Ruby guide Makira, the tech genius, Adheeb and Imam work with Catara the spy, and Daniel, James and Louis direct fearless Vennvo. To transmit the virus the freedom fighters will need to access the Command Deck. With AI Sciron having put the station in lockdown Skye needs the commanders to help find a way through the space station's biogarden tunnels, past the evil Morka, to get to the command deck. If they succeed they'll be that much closer to being able to help Skye save the Kaladians.