Four teams of commanders guide their avatars on a mission to help Skye fight back against a rogue AI named Sciron. Commanders Wills and Hills direct Vaygus the smuggler, Diana, Sian and Dammi guide cool-under-pressure Tal, Alex, Tzavier, Will and Harry work with Catara the spy, and Christopher and Francesca choose brainiac Dexx to try to escape the Perfection Lab and download the crucial data files from Dr Kline. If any of them can succeed it will help Skye build an antivirus and start the fightback against Sciron.

Commanders Bailea and Noah direct Makira the tech genius, Akean, Corelle and Manon guide stealthy Zarq, Luke and Lincoln work with Vaygus the smuggler, and Zahraa and Natalie choose cool-under-pressure Brodie to try to retrieve the crucial antivirus element from the cargo bay and continue the fightback against Sciron. If any of them can succeed it will help Skye develop an antivirus and save her people.