Commanders Bailea and Noah direct Makira the tech genius, Akean, Corelle and Manon guide stealthy Zarq, Luke and Lincoln work with Vaygus the smuggler, and Zahraa and Natalie choose cool-under-pressure Brodie to try to retrieve the crucial antivirus element from the cargo bay and continue the fightback against Sciron. If any of them can succeed it will help Skye develop an antivirus and save her people.

Commanders Lexi and Ethan choose Dexx the tech genius Ben, Jamie and Ben guide Vaygus the smuggler, Logan, Bobby and Cody work with Zarq the secret agent, and Ayesha, Daniyal and Maria direct cool-under-pressure, Tal. They have to make it through the cyber factory to test the antivirus. If any of them can succeed, it will help Skye to save her people.