Luke and Lizzy have been inseparable since childhood. Now all grown up and in their 30s, they have decided to have a baby - in a non-traditional way. Lizzy, who is gay, is really ready to become a mom and who better to be the dad than her best friend Luke. Then, just as Lizzy discovers she is actually pregnant, Luke surprises her with the news that he has fallen in love and married Prudence, a free-spirited, British beauty who was due to go back to England in a matter of days. Suddenly, a different kind of family is born and the three must learn how to make it work together.

On a group trip to the gym, Lizzy spies her secret crush, Kate and with the help of Luke, and Prudence, she initiates a conversation that leads to some plans for group bowling. Later, Luke and Prudence help get Lizzy an appointment with the best OB-GYN in the city and Lizzy is ecstatic - until they arrive to a big surprise. Meanwhile, Prudence realizes that Lizzy's pregnancy is making her feel left out and Leisha helps her explain her feelings to Luke.