On Jennifer's orders, Yorick and Agent 355 search for a geneticist who can unravel the mystery of how he survived. Meanwhile, Hero and Sam encounter a dangerous group of women.

Yorick, Agent 355 and Dr. Mann hit a snag on their way to San Francisco. As the search for 355 heats up, Jennifer clashes with former cabinet secretary Regina Oliver, who has her eyes on the presidency. Hero is seduced by a charismatic leader, Roxanne, as Sam and Nora grapple with their place in a dangerous group of survivors.