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Supergirl battles a scientist who has been possessed by an alien parasite, giving the ability to drain the lifeforce from anyone he touches. Meanwhile, Alex comes out to Kara, and the Guardian makes his first public appearance.
Cadmus provides a gang of crooks with alien weaponry in an attempt to spread fear and panic among the populace. Meanwhile, Kara tries to mentor Mon-El with minimal success, and James decides that he wants to be a superhero.
While Cadmus captures Supegirl and Mon-El, Guardian and Winn go after a murderous vigilante that is letting Guardian take the blame for his murders. Meanwhile, Alex and Maggie have issues.