Mon-El and Imra decide whether to help the DEO battle Reign. Meanwhile, another Legionnaire attempts to help Kara emerge from the coma that Reign put her into after their battle.

Morgan believes that a recent attempt on his life was made by Lena. When Lena is poisoned, Kara steps in to find out who is responsible for the escalation in hosility. Meanwhile, Sam turns to Alex for help determining the cause of her blackouts.