M'yrnn tries to redirect his mental processes and ends up infecting the DEO with a telepathic rage virus. Meanwhile, Lena tries to convince Sam that the latter transforms into Reign during her blackouts.

Supergirl discovers that she has a mental link to Sam and Julia, and takes Lena and Alex with her to rescue them. Meanwhile, James faces a tough decision when he must decide whether to investigate Lena or not after she kept Reign's existence a secret.