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Kara tries to convince an Amertek insider to provide her with information proving a connection to Lex. Dreamer agrees to a TV interview, and Brainiac-5 helps James explore the cause of his PTSD.
Supergirl and Lena go to Stryker's Island to check out Lex's cell, and find a clue to his schemes. Supergirl is declared a criminal and is forced to question whether she does more harm or good, while James deals with the fallout from being injected with the serum.
Kara and Lena track Lex to Kaznia, and find Eve but no Lex. Ben abandons his son to go after his wife's killer, which pits him against Brainiac-5, Dreamer, and the newly superpowered James. Alex and Kelly travel to meet with a woman giving birth to a child who could become Alex's.