James undergoes surgery to replace his shattered spine, and Lena has no choice but to work with her brother Lex to perfect the Harun-El serum to cure James before he dies. J'onn and Kara track down Manchester, who has recovered the Staff of H'ronmeer and attempts to turn J'onn from the path of peace.

J'onn has a meeting with his deceased father, while Supergirl, Alex, and Lena join forces to track down Eve and locate Lex.