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Leviathan's leader comes after Lena to get the medallion, and Lena convinces Supergirl to take her to the Fortress to find a weapon capable of stopping him. Kelly makes a confession to Alex, and John reaches out to his brother.
The connection between Lena and Andrea is explored via flashback, as Lena attempts to redeem her stepbrother's legacy. In the present, Leviathan launches an attack on the DEO to eliminate Rip Roar.
Alex is torn between destroying Lena before she can unleash Myriad, or using Malefic to stop the Luthor's mind-control plan. Meanwhile, Khan prepares to wipe humanity from the planet.