The connection between Lena and Andrea is explored via flashback, as Lena attempts to redeem her stepbrother's legacy. In the present, Leviathan launches an attack on the DEO to eliminate Rip Roar.

Alex is torn between destroying Lena before she can unleash Myriad, or using Malefic to stop the Luthor's mind-control plan. Meanwhile, Khan prepares to wipe humanity from the planet.