Set against the vibrant backdrop of one of the world's hottest cities - Miami - private pathologist Dr. Beaumont Rosewood, Jr. must crack a case that hits close to home. As he begins his investigation, Detective Annalise Villa gives him a run for his money as they cross paths and are forced to work together to help the Miami PD solve the case.

A series of mysterious deaths pulls Rosewood off the glamorous promenades of South Beach when a troubled young genius stands accused of murder, and the only one who believes in his innocence is Rosewood. He must contend with a colorful new adversary, escalating health problems and a burgeoning romantic relationship, while Villa's inability to connect with people hampers her own ability to investigate the case.