Rosewood and Villa dive into the hip Miami art scene to catch a serial killer who is on the cusp of creating a "masterpiece." When TMI's ex-fiancé, FBI Detective Heath Casablanca, joins the hunting party, he threatens to sabotage Pippy and TMI's relationship. Heath also butts heads with Hornstock, who stands to take over as police chief if he can catch the killer. Meanwhile, an impending lawsuit against Rosewood threatens the lifeline of Magic City Lab and forces Donna to take a long hard look at the way her son lives his life. Also, Rosewood tries to protect Villa from his best friend, Mike.

Hornstock forces Villa to pick a new partner, and she immediately clashes with the one assigned to her. After learning she cost Hornstock the job as Chief, Villa tries to make herself less of a liability, which reveals a surprising pattern in her life. Meanwhile, the death of a victim forces Pippy to offer her assistance in the investigation and to revisit her past. The case stirs up old wounds for the entire Rosewood family and creates new ones for her and TMI. Meanwhile, Rosewood's slight health scare leads him in search of a new cardiologist.