When a female astronaut is found dead, Rosie and Villa launch into an investigation of America's space program. Rosie navigates new dynamics regarding his latest health issue, and Villa's long-lost brother returns to Miami.

Rosewood and Villa head back to Villa's roots in Little Havana to investigate a vigilante who may be guilty of murder. Villa learns that her brother, Marcos, has a surprising connection to the case, and Rosie receives news of a complication regarding his kidney transplant.