A hostage situation erupts at the East Miami Police Department, and Rosewood, Villa and Slade are trapped on the inside. Rosewood forms a strong bond with their captor and must solve his biggest medical mystery to date in order to keep his team alive.

When an escape artist is found dead in a wooden trunk, Rosewood and Villa must unravel a case packed with illusions and deception. Meanwhile, Hornstock's days with the East Miami PD may be numbered and Rosewood gets to know Adrian to make sure he is the right guy for Villa.