In Alone's driest location yet, ten new participants must survive in the Great Karoo desert as they face extreme temperatures, new species of predators, and a host of exhausting challenges, all for a chance to win $500,000. With big game more abundant than ever, some play the odds, while one survivalist gets hit with a debilitating infection.

Faced with skittish game and unfamiliar plants, the final group of survivalists quickly learns their earliest strategies will be met with unforgiving resistance.