Hondo teams up with an old DEA friend, Special Agent Katrina "K.C." Walsh, on a task force aimed at unmasking the secret leader of a fentanyl drug smuggling ring. Also, Jessica and Michael Plank, president of the Police Commission, begin implementing her new law enforcement community initiatives.

Hondo and Jessica's secret relationship comes to a crossroads when Michael Plank, the president of the police commission, discovers their affair. Also, when Hondo and the team assist with the federal investigation to bring in an undocumented fugitive, they find themselves at the center of a citywide immigration debate.