Mississippi Valley, 1605: Indians lock French explorers into a chamber in which they get disintegrated. 2001: Sydney and her student Adam seek his ancestors' fabled Eyes of Toklamanee, but they are pursued by mysterious gunmen.

While on a lecture tour with Nigel in Europe, Sydney is contacted by MI-5 because she is the only one who can prevent an impending high-level assassination, according to a prophecy written by Nostradamus.