The Pack receive genetic and technological upgrades to their bodies from Coyote and prove to be more than a match for Goliath, Elisa, Bronx and Hudson, who are captured. Meanwhile, vying for place as second in command, Brooklyn, Lex and Broadway must come up with a plan to free their friends and defeat the Pack.

Elisa attempts to restore her relationship with her brother while Goliath tries to find a cure for the mutates.