Neil deGrasse Tyson interviews puppeteer Frank Oz, then discusses puppets in pop culture with comedian Adam Conover and astrophysicist Charles Liu. Comedian Chuck Nice interviews people at the New York Comic-Con. Andy Serkis, a performance-capture actor, joins them to discuss the art and science of character creation. Bill Nye, the Science Guy, also comments.

Neil deGrasse Tyson interviews astronaut Scott Kelly, then discusses the science of human space flight with comedian Sasheer Zamata and astronaut Terry Virts. Comedian Chuck Nice interviews people in New York City. Jennifer Fogarty, a NASA biomedical scientist, discusses effects of space on the human body. Bill Nye, the Science Guy, also comments.