Adam's quest to find the best sandwich in America takes him to the Gulf Coast where he'll crown a region champ. Will it be the famous shrimp po' boy, Cuban medianoche sandwich or grouper Reuben sandwich?

Adam's quest for the best sandwich takes him to the Midwest where he'll sample Chicago's 4-courser and Al's Italian beef sandwiches, as well as, St. Louis' heart-stopping BLT sandwich.