A prison transport plane en route to a high-security facility in Colorado is overtaken by its convict passengers, with Terrell and Grace aboard. Meanwhile, Sammo tries to locate the missing plane and his friends.

Dozens of police officers, including Amy, become deathly ill when someone sprays several precincts with an unknown biological agent. Meanwhile, Sammo and Terrell try to track down the culprit and retrieve the antiserum needed to save their colleagues.