Dozens of police officers, including Amy, become deathly ill when someone sprays several precincts with an unknown biological agent. Meanwhile, Sammo and Terrell try to track down the culprit and retrieve the antiserum needed to save their colleagues.

Sammo dons a Santa suit to discover why thieves, also dressed as St. Nick, are stealing a popular holiday doll from various toy stores. He also becomes obsessed with finding a missing boy, after the kid's brother tells him that all he wants for Christmas is to have him home again.