When vacationing guests at a tropical family resort began dropping due to respiratory problems, Dr. Connor choppers in to assess the fast-spreading disease that has many contrary symptoms, forcing him to quarantine the entire island -- a bold decision that spells bad publicity for the anxious hotel company. Meanwhile, Dr. Durant stays behind in nearby Miami to run extensive lab tests and help the desperate Connor narrow the odds of finding the source of the deadly contagion.

When several tough college football players fall victim to a mysterious nerve disease, Dr. Connor and Dr. Durant initially consider multiple sclerosis but when campus sorority sisters also become ill, the NIH team must hustle to find the missing link before a horde of alumni arrive for the homecoming game. During their probe, they suspect some murky information is being held back by the students -- crucial clues that might lead them to steroids or designer drugs.