Fantini, the world champion in 'Ultimate Fighting' shows up in Buenaventura wanting to buy the whole island to turn it into a holiday paradise. He uses brutal violence to reach his goal but gets challenged by Rio and Wiley.

Costa Perdida is struck by a virus epidemic. The government is doing nothing to stop the disease. On the contrary, they are doing all they can to cover up the epidemic. The only ones battling the deadly killer-virus are Rio, Wiley and sexy epidemic-expert Dr. Harley Shaw. Suddenly, Rio starts getting the symptoms of the disease...