When paramedics rush in with a stabbing victim, Villanueva is stunned to realize that the patient is his own son, Nick. Now it's up to Sydney and Hooten to save the young man. With Ty's help, Sung attempts to restore a concert violinist's perfect pitch by removing an astrocytoma that is pressing on the musician's brain. And Buck receives a strange request from the donor in a failed kidney transplant.

During Monday's 311 conference, Hooten calls Dr. Stewart Delany to explain how a careless mistake killed Delany's young patient. But the outcome of the conference leaves the hospital's surgeons conflicted. Sydney and Villanueva operate on Keith Harriman, a young man with extensive injuries from an apparent suicide attempt. Sydney and Buck wonder about the resources wasted on those who cannot or do not want to be saved. And Mark Ridgeway returns, determined to make Ty and Tina pay for their adultery.