Narcotics smuggler Dino Patrone returns to the United States after visiting the old country for several months. He brings his younger sister Carla with him as she plans on studying in the U.S. Little does Dino know that his boss Victor Bardo has ordered his best friend Willie Asher to kill him. Traveling on the train to Chicago, Dino meets an acquaintance, print and radio journalist Loren Hall. Dino soon meets his end and it falls to Hall, who reluctantly agrees to work with Eliot Ness, to help Carla Patrone after she is kidnapped by the mobsters.

Having had three boyfriends killed in the last 18 months, Francie West has earned her nickname, the kiss of death girl. She is a blackjack dealer in Phil Corbin's speakeasy and has been dating a minor mobster in Lou Scalese organization named Whitey Barrows. Corbin has plans to move into the big time and with Whitey's help, hijacks four truckloads of liquor belonging to Scalese. Corbin kills Whitey when the job is done and Eliot Ness tries to get Francie to help him out on the case.