Mobster Victor Salazar is out to steal a commercial shipment of morphine destined to a Chicago medical facility. Before he can do so however, it's snatched out from under him by one of his henchman, Steve Ballard. With Eliot Ness and his men have been keeping a close eye on Salazar, the drug kingpin desperately tries to find the junk. What he doesn't know is that another of his underlings, Barney Howe is actually Barney Retsick, a Federal narcotics Agent. Retsick and Ness work together to arrest all of the criminals before the narcotics, disguised as children's candy, hits the streets.

Frank Nitti decides to import a large amount of heroin - $2 million worth. Eliot Ness is soon onto him and arrests the delivery man, Mr. Yang from Shanghai, but he no longer has the goods and they have no reason to detain him. Ness and one of his men travel to San Francisco to see if they can determine how the goods were smuggled into the country and determine that it entered on a passenger cruiser and was then shipped by air to Chicago enclosed in a large globe.