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When Fred's allergies become so extreme that he sneezes a hole in the TV screen, Fred decides to take medicine pills called "Scram" from a store which has the disastrous side effect of turning into an ape.
Gazoo convinces Fred to do a Monopoly game with Wilma to spice up their relationship for "togetherness" in their marriage, but things make a turn for the worse when they begin to fight, and Fred decides to stay with Barney, and Wilma stays with Betty until they can make up.
After Fred criticizes a novel about the future that Barney is reading, The Great Gazoo sends Fred, Barney, Betty, and Wilma into the 21st century.