David 'Brown' and a young widow he has never met before are framed for the murder of her husband by a corrupt sheriff and his men. Handcuffed together, the two of them make their escape.

Hoping to avoid situations which leads to his transformation into the Hulk, David 'Bailey' isolates himself in a remote wilderness of Baja California, Mexico, and begins to live there temporarily. But his peaceful camping site is disturbed by the arrival of a female medical fugitive who was wrongly accused of malpractice by the father of a girl who died in her care.