It's an epic "family" reunion when the cast of "Scrubs," led by Zach Braff and Donald Faison, face off against Neil Flynn and his "Beer Shark Mice" improv crew as they test their skills and compete for charity. In the next game, actor Wendi McClendon-Covey, along with her family and "Generation Ripe" podcast partner, go head-to-head against actor Patrick Warburton and his family.

JoJo Siwa, the D'Amelio family, Loni Love and Ross Matthews compete for their respective charities.