Reese Witherspoon serves as the celebrity guest announcer during the series premiere of this variety show hosted by Neil Patrick Harris, which features A-list stars, performances, stunts, comedy skits, mini game shows, audience giveaways and hidden camera pranks. Based on the British series "Ant & Dec's Saturday Night Takeaway."

Celebrities participate in stunts, comedic skits, performances, mini game shows, giveaways, pranks and more; guest announcer Tyler Perry.