The doctors find their own lives in danger when they arrive at the scene of a massive multi-vehicle accident on a highway covered in thick fog. Also, Jesse's confidence is shaken following his heart attack, while Carla's condition becomes critical.

Angus' older brother, an "all-star" ER doctor, tries to secure a position at Angels Memorial. Meanwhile, Christa's romantic feelings towards Neal begin to grow; and Malaya deals with a patient who is obsessed with her.