Christa experiences her busiest shift yet when she is responsible for all emergencies at Angels Memorial that occur outside of the E.R. Meanwhile, Mario bonds with an older patient with HIV; Malaya starts a bone marrow drive for Carla; and Leanne refuses a date with Cole.

Leanne is rattled at the thought of losing Jesse as he fights for his life after suffering a massive heart attack. Also, Mario asks the residents to cover for him when he searches the city for a patient's son, disobeying Neal's direct order not to leave the hospital.