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The doctors work with the Center for Disease Control and Prevention to find an antidote to the deadly viral outbreak at Angels Memorial. Also, Leanne makes a life-changing decision, and Jesse welcomes a new batch of residents.
The ER is quarantined when a viral outbreak jeopardizes the lives of the doctors and patients at Angels Memorial. Also, Ariel, the young girl Leanne bonded with a year ago when she lost her father, returns to Angels.