RFK Jr.'s anti-science policy triggers CDC resignations. Also, two children are dead and 17 people are injured in a mass shooting at a Minneapolis Catholic school. Plus, a Trump-appointed federal judge excoriates the Trump Justice Department in a scathing new ruling. And an Iowa Democrat flips a long-held GOP state Senate seat. Dr. Ashish Jha, Rep. Ro Khanna, Rep. Maxwell Frost, J. Michael Luttig, and Iowa state Senator-elect Catelin Drey join Ali Velshi.

A federal appeals court deals a huge blow to Donald Trump on tariffs. Also, Trump is blasted for his "illegal" tactic to cut foreign aid. Plus, Trump special envoy Steve Witkoff refuses to blame Russia as the aggressor against Ukraine. And Iowa GOP Sen. Joni Ernst won't seek reelection in 2026. Laurence Tribe, Rep. Lloyd Doggett, Norm Ornstein, David Rothkopf, Iowa State Rep. Josh Turek, and Ben Wikler join Ali Velshi.