Jeremy Vine hosts as Melvin Odoom and Miles Jupp join team captains Carol Vorderman and Sally Lindsay to prove their skills in tricky games and mind-twisting challenges.

Dr Ranj Singh partners with Carol Vorderman, and John Thomson joins forces with Sally Lindsay. The teams race through challenges like In Other Words, Word Block and Join the Dots. Will Dr Ranj's hospital smarts or John's comedic quick thinking prove the ultimate puzzling advantage?