When Intelligence follows up on a tip Antonio and Halstead received from a reliable informant about an upcoming drug trade, the team is shocked to discover the mutilated body of a man. Upon further investigation, the body is identified as a government official and when Olinksy, Ruzek, Lindsay and Halstead question the man's acquaintances they discover he had access to very important devices. Meanwhile, Burgess helps plan a surprise for Platt.

A doctor with personal connections to Voight is under investigation when four of his patients are committed to Chicago Med after an overdose of chemo. The doctor denies Lindsey and Halstead access to his files, but after obtaining a warrant the team is able to track down his patients and discover all of them have been poisoned with unnecessary chemo. Meanwhile, Burgess and Platt work together to clear Roman's name.