DiNozzo is reunited with his ex-girlfriend, Jeanne Benoit, when insurgents in Sudan attack a group of volunteer doctors, including her husband. DiNozzo and McGee travel to the crime scene for the joint murder and kidnapping case and join the search for the missing doctors.

In the hopes of sparing a family further tragedy, the Secretary of the Navy calls on NCIS to help a sailor battling leukemia locate a bone marrow transplant after his two Marine siblings are killed in the line of duty. Also, Bishop returns home to Oklahoma for the Thanksgiving holiday.