At just 18 years old, Loren was involved in a catastrophic forklift accident. To save his life, doctors cut him in half. Sofia was an active 29-year-old when her heart went into end-stage failure. Now she must be plugged-in to stay alive.

Lukas has Parry-Romberg Syndrome, causing half his face to shrink inward. Stefani's rare muscular dystrophy leaves her dependent on her mother but craving independence. Ellie says steroid withdrawal left her with lizard skin and seeks a cure.