Zahra is housebound by a rare condition, but new prosthetics may be her ticket to freedom. Mahogany's leg weighs nearly 100 pounds due to lymphedema. Joseph was born without a jaw but won't let it stop him.

Piyah must walk on her hands because she was born with a body that ends at her waist. Joe is the first survivor of a successful hands and face transplant. Tumors have left Reggie's face unrecognizable, and his independence.