Dr. Jeff fights to save a pit bull bitten by a rattlesnake. The team battles to save a cherished cat rescued from an apartment fire. And, Dr. Amy performs emergency surgery when a girl's beloved Chihuahua is hit by a car.

Dr. Jeff and his team head to Houston to rescue dogs in the aftermath of devastating floods. Back in Denver, Dr. Amy treats a cat with a mysterious wound, and a young Lab needs emergency surgery after eating something unusual.