A daredevil dog is saved by Dr. Jeff after it jumped from a fast-moving car on the highway. Dr. Don solves a medical mystery, while a couple's mischievous rescue guinea pigs cause a stir.

Dr. Jeff and his team lend a hand at Lakota Reservation in South Dakota. Back at the clinic, Amy debates emergency surgery for a French bulldog who ate his favorite toy, while Susan finds the perfect forever home for a lovable canine called Koda.