When Brian's closest relationships implode due to his inability to cut ties with Eddie Morra, he goes rogue from the FBI to free himself from the senator's control. In Russia, he searches for Piper, Morra's former associate turned adversary, and her alternative NZT vaccine. Also, Rebecca comes closer to discovering Brian's connection to NZT and Senator Morra.

When Rebecca learns the truth about her father's death, she takes NZT for the first time and uses it to seek justice for his murder. Also, Sands makes a dangerous move against Brian to ensure the success of his new initiative.