Brian Finch's life takes an extraordinary turn when he uses a mysterious drug, NZT, that allows him to access his full brain capacity. However, when an NZT-related murder lands Brian on the FBI's radar, he uses the drug in an attempt to stay ahead of the authorities long enough to clear his name.

When Brian helps Agents Harris and Boyle investigate the murder of a retired FBI agent, they're shocked to find a link to the elusive head of a notorious drug cartel. Also, Brian reconnects with an old flame, Shauna, but worries her renewed interest is really in the NZT version of him.