When Sands, Senator Morra's deadly representative, enlists Brian's help to eliminate an immediate threat he needs to keep secret from the politician, Brian learns Sands' dangerous and shocking past. Also, Brian's sister, Rachel, scrambles to cover up his abrupt side mission with Sands when the FBI can't reach him regarding a new case.

When Brian's closest relationships implode due to his inability to cut ties with Eddie Morra, he goes rogue from the FBI to free himself from the senator's control. In Russia, he searches for Piper, Morra's former associate turned adversary, and her alternative NZT vaccine. Also, Rebecca comes closer to discovering Brian's connection to NZT and Senator Morra.